Enzymatically-stable oxetane-based dipeptide hydrogels

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Enzymatically-stable oxetane-based dipeptide hydrogels.

Low molecular weight gelators that are not easily degraded by enzymes have a range of potential applications. Here, we report new Fmoc-protected dipeptides in which the amide carbonyl group has been replaced by an oxetane ring. Remarkably one of these peptidomimetics, but not the corresponding dipeptide, is an effective gelator, forming hydrogels at a concentration of 3 mg mL-1. On assembly, th...

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Enzymatically cross-linked hydrogels and their adhesive strength to biosurfaces.

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Controlling the network type in self-assembled dipeptide hydrogels.

We show that the same low molecular weight gelator can form gels using three different methods. Gels were formed from a high pH solution either by adding a salt or by adding an acid; gels were also formed by adding water to a solution of the gelator in an organic solvent. The mechanical properties for the gels formed by the different methods are different from one another. We link this to the n...

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ژورنال

عنوان ژورنال: Chemical Communications

سال: 2018

ISSN: 1359-7345,1364-548X

DOI: 10.1039/c7cc09701h